Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development
نویسندگان
چکیده
منابع مشابه
Alpha-2 adrenergic receptor functional coupling to G proteins in rat brain during postnatal development.
During postnatal development, alpha-2 adrenergic receptors (A2AR) change in both density and distribution. In forebrain, receptor density increases about 4-fold over neonatal levels, reaching adult levels before postnatal day (P) 28, whereas in hindbrain, including cerebellum, there is a decrease in overall receptor density. We examined the coupling of A2AR to G proteins using agonist-stimulate...
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متن کاملAlpha-2 Adrenergic Receptor Functional Coupling to G Proteins in Rat Brain During Postnatal Development H. KEVIN HAPPE, DAVID B. BYLUND, and L. CHARLES MURRIN
During postnatal development, alpha-2 adrenergic receptors (A2AR) change in both density and distribution. In forebrain, receptor density increases about 4-fold over neonatal levels, reaching adult levels before postnatal day (P) 28, whereas in hindbrain, including cerebellum, there is a decrease in overall receptor density. We examined the coupling of A2AR to G proteins using agonist-stimulate...
متن کاملBeta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2011
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2011.06.045